How To Repair Damaged Nerves – A new recipe for patterning cells onto a surface holds promise for the repair of damaged nerve tissue.
The researchers, led by Jeffrey Schwartz, Professor of Chemistry, and Jean Schwarzbauer, Eugene Higgins Professor of Molecular Biology, have developed a technique to adhere and align cells in a soft, flexible material, known as a hydrogel, with the goal of creating a scaffold. . in which to grow neurons and provide guidance for the cells to extend the long, thin projections, or axons, that serve as transmission lines of the nervous system.
How To Repair Damaged Nerves
A new recipe for patterning cells onto a surface holds promise for spinal cord injuries. Professors Jeffrey Schwartz and Jean Schwarzbauer discuss the potential of their project in this video filmed before the COVID-19 pandemic.
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“Our hope is that by using that technology, if axon reconnection occurs, we will be able to see restoration of function,” Schwartz said. “Spinal cord injury is devastating, and if we could address some of it, it would make us extremely happy.”
A key challenge was finding ways to make cells adhere to hydrogel, a material consisting of a watery natural or synthetic polymer that resembles unset gelatin. To overcome this challenge, the researchers devised a method to apply a layer of cell adhesive on top of the hydrogel. First, the team applied a hydrophobic (water-repellent) solvent that allowed a layer of titanium or zirconium oxide to form on the surface of the hydrogel. The next step is the self-assembly of a phosphonate monolayer, attached to the titanium or zirconium oxide coating, which is attractive to cells. By initially masking parts of the hydrogel surface, the researchers can create precisely defined adhesive regions, allowing cells to be patterned and a patterned extracellular matrix to be assembled into arrays that are useful for neural repair.
This research was presented at the annual Celebrate Innovation (CPI) event in November 2019 that highlights the work of faculty and student researchers who are making discoveries and creating inventions with the potential to have broad societal impact.
This year, CPI is part of Engage 2020, a multi-day virtual conference taking place November 4-6 to create new connections between innovators and leaders in entrepreneurship, industry, nonprofits, and governance across ecosystems. of state, regional and global innovation. . The CPI portion of the program is from 3:30 p.m. m. to 6 p.m. m. Thursday November 5. I probably don’t spend much time thinking about his nervous system, but without it, his body parts couldn’t communicate with each other, be it eating, walking, or notifying him of pain somewhere in his body. body.
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The nervous system has two components: 1) the central nervous system (brain and spinal cord) 2) the peripheral nervous system, or nerves that run throughout the body to the spinal cord and then to the brain.
The good news is that there are vitamins and supplements that benefit nerve health. Here are the top six.
What it is: ALA is a powerful fat- and water-soluble antioxidant that neutralizes free radicals. Unlike other antioxidants, which target free radicals in the blood or tissue, ALA is effective on both.
Why it matters: Blood sugar spikes can generate free radicals and damage nerves and nerve health. Supplementing with ALA not only fights free radicals, but also supports blood sugar levels already in the normal range by helping cells recognize and respond to insulin.
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What you need: 50–100 mg is the recommended dose for most people. People with blood sugar problems may benefit from up to 600mg daily
Why it’s important: Because it’s critical for serotonin, a neurotransmitter involved with mood, appetite, sleep, learning, and more. Some studies show that vitamin B12 can improve your mood. Other research links low B12 levels to bone health in women older than 64 and memory in older people.
What it is: Known for its ability to promote general well-being, vitamin B6 is found naturally in many foods such as meats, potatoes and starchy vegetables, and non-citrus fruits.
Why It’s Important: In addition to supporting healthy nerve function and synthesizing neurotransmitters like serotonin and dopamine, some studies have shown that B6 may support heart health by lowering levels of a key amino acid in the blood. Low B6 has also been linked to certain types of health problems.
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What you need: Most people get an adequate amount of vitamin B6 from food alone or from multivitamins. But in this case, you may be getting too much of a good thing: Taken in doses greater than 250mg per day, vitamin B6 can have a toxic effect on the nervous system. Limit yourself to doses less than 100 mg per day to be safe.
What they are: From beta-carotene to the vitamin, antioxidants are a supercharged group of compounds that fight free radicals. Antioxidants are commonly found in brightly colored fruits and vegetables, as well as spices like cloves and beverages like tea.
Why They’re Important: Antioxidants are credited with supporting a healthy immune system and healthy aging. And, because they target nerve-damaging free radicals, they can minimize trauma.
What you need: Find a balanced antioxidant formula that includes 400 IU of natural vitamin E, 200 mcg of selenium, and at least 500 to 1,000 mg of vitamin C.
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What they are: Omega-3 essential fatty acids are found naturally in cold-water fish like salmon, as well as leafy green vegetables, walnuts, flaxseed oil, and hemp seed oil.
Why They’re Important: Omega-3s play a role in the healthy function of brain cells and neurotransmitters. They are credited with supporting healthy cholesterol and blood pressure levels already in the normal range, along with brain health.
What you need: Most women will benefit from 250 to 500 mg of EPA and 500 to 1,000 mg of DHA; men should aim for 360–800 mg of EPA and 100–500 mg of DHA daily.
What it is: Vitamin D is a fat-soluble vitamin that helps the digestive system absorb and regulate calcium and phosphorus. Most people know that we get vitamin D from sunlight, but it is also present in oily fish and egg yolks.
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Why it’s important: Vitamin D can support healthy bones and healthy blood pressure levels already in the normal range. It can also be beneficial for those with nervous health problems.
What you need: Most adults should aim for 600 IU a day; those over 70 can increase their intake to 800 IU.
By keeping your nerves healthy, you increase your chances of maintaining a long and active life throughout the years. Be sure to check out these nutrients today.
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By registering, you agree to receive offers and promotions from Botanic Choice. You can unsubscribe at any time. Product prices are subject to change without notice. Discounts and promotions are valid for one use only and cannot be combined or applied to previous and pending orders. Sometimes due to an injury, the nerves in the body can be damaged. This is common in hand or finger injuries, because the nerves are close together and not as well protected by skin and muscle. These injuries can also occur on the feet and toes. If the nerves are only bruised in an injury, they tend to heal on their own. If the nerves are cut, they will most likely be painful and not heal. You can also develop something else called a neuroma, which is a small, non-cancerous growth on the nerves. In this case, nerve repair surgery is an excellent option to relieve pain and restore sensation.
Most of the time, the injury is the cause of the nerve damage. This specifically involves injuries such as deep lacerations to the hand or fingers. These can cut the nerves, and many doctors can just sew up the wound and hope that the nerves can grow back together. In some cases, they don’t heal properly or are too cut to heal. This type of injury needs to heal before surgery can be done. Nerve repair surgery is often mentioned as an option after an injury heals, but nerve pain persists. Nerves are made up of two parts, a sheath known as an epineurium, and nerve fibers. If only the epineurium is damaged, this is a bit easier to repair.
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As with most hand surgeries, the patient will be placed under local anesthesia. The hand will be cleansed and
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