Non Prescription Flea And Tick Chewables For Dogs – Home > Prescription Pets > NexGard Flea & Tick Chews for Dogs > NexGard Chews for Dogs 60.1-121 lbs (1 chew) Red
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Non Prescription Flea And Tick Chewables For Dogs
Home > Best Dog Treats > NexGard Dog Flea & Tick Chews > NexGard Dog Chews 60.1-121 lbs (1 chew) Red
Nexgard Chewables For Dogs 60.1 To 121 Lbs, 1 Month Supply
Home > Shop by Category > Heartworm, Flea & Tick Protection > NexGard Dog Flea & Tick Chews > NexGard Dog Chews 60.1-121 lbs (1 chew) Red
Home > Heartworm, Flea & Tick Protection > NexGard Dog Flea & Tick Chews > NexGard Dog Chews 60.1-121 lbs (1 chew) Red
Drug compounding is often thought of as the process of combining or mixing drugs to create drugs that are tailored to the needs of an individual patient.
NexGard Flea & Tick Chewables for Dogs is the new, revolutionary flea and tick preventative from Frontline®, the #1 choice of veterinarians. It’s the first flea and tick killer of its kind, as it comes in a delicious, beef-flavored soft chew that protects your dog against flea and tick infestations for up to 30 days. So you no longer have to worry about messy topicals or accidentally washing it off your dog while bathing! It can be taken regularly along with your dog’s heartworm medication for your convenience.
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NexGard protects your pet from larger fleas by killing them before they lay eggs, reducing the chance of flea infestation. It also kills the American dog tick, reducing the risk of tick-borne death in your pet.
NexGard kills adult fleas and is indicated for the treatment and prevention of fleas (Ctenocephalides felis), as well as the treatment and control of the black-legged tick (Ixodes scapularis), American dog tick (Dermacentor variabilis), Lone star tick (Amblyomma americanum). , and the brown dog tick (Rhipicephalus sanguineus) in dogs and puppies 8 weeks of age and older, weighing 4 pounds or more, for one month.
NexGard contains a new ingredient not used in any other flea and tick protection. Afoxolaner, the ingredient in NexGard, is rapidly absorbed into your pet’s bloodstream where a good concentration makes your pet’s blood toxic to insects without affecting your pet’s health. Afoxolaner is slowly metabolized, and it will remain in your pet’s blood for up to 30 days at the appropriate concentration.
When a flea or tick tries to feed on your pet’s blood, Afoxolaner interferes with important neurotransmitters and affects their central nervous system, causing instant death. This means your pet gets amazing protection in one delicious bite! NexGard is a prescription only drug, so talk to your vet about using it for your pet.
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NexGard can be administered with or without food. Care should be taken to ensure that the dog consumes the full dose, and the treated animal should be observed for a few minutes to ensure that part of the dose is not lost or rejected. If you suspect that any of the dose has been missed, or if vomiting occurs within two hours of taking it, take it again with another full dose. If a dose is missed, administer NexGard and resume the monthly dosing schedule.
NexGard treatment can be started at any time of the year. In areas where fleas are common throughout the year, monthly treatments with NexGard should be continued throughout the year.
It is important to treat all indoor animals with an approved flea product to reduce the likelihood of reinfestation with fleas.
Not for human use. Keep this and all medicines out of the reach of children. In case of accidental ingestion, seek medical attention immediately.
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The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. Use with caution in dogs with seizures (See Adverse Reactions).
In a well-controlled US field study involving a total of 333 households and 615 treated dogs (415 afoxolaner; 200 active controls), no serious adverse reactions were observed with NexGard.
1% of observations over three months are given in the table below. The most commonly reported adverse reaction was vomiting. The occurrence of vomiting was generally self-limited and short-lived and tended to decrease with subsequent doses in both groups. Five treated dogs developed anorexia during the study, and two of them developed anorexia at the first dose but not at subsequent doses.
In a US field study, one seizure-prone dog developed a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. This dog had a third seizure a week after receiving the third dose. The dog remained enrolled and completed the study. Another dog with a history of seizures had a seizure 19 days after receiving the third dose of NexGard. The dog remained enrolled and completed the study. A third dog with a history of seizures received NexGard and had no seizures during the study.
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To report suspected adverse events, obtain technical assistance, or obtain a copy of the MSDS, contact Merial at 1-888-637-4251 or www.merial.com/nexgard. For additional information on animal drug experience, contact the FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth.
Afoxolaner is a member of the isoxazoline family that binds at the binding site to inhibit insect and acarinal ligand-gated chloride channels, specifically channels gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby allowing chloride to cross pre- and post-synaptic cell membranes. transfer of ions. Prolonged afoxolaner-induced hyperexcitability leads to uncontrolled central nervous system activity and death of insects and acarines. The selective toxicity of afoxolaner between insects and acarines and mammals can be inferred by the differential sensitivity of insect and acarine GABA receptors versus mammalian GABA receptors.
99% efficiency in eight hours. In a separate well-controlled laboratory study, NexGard was 100% effective against adult fleas at 24 hours post-infestation for 35 days and ?93% effective up to day 21 and at 12 hours post-infestation on day 35. On day 28, NexGard was 81.1% effective 12 hours after infection. Dogs in treated and control groups covered with fleas on day 1 produced flea eggs at 12 and 24 hours post-treatment (0-11 eggs and 1-17 eggs in NexGard-treated dogs and 4-90 eggs and 0 in control dogs -118 eggs, 12 and in 24 hours). At follow-up post-infestation evaluations, fleas from dogs in the treated group failed to produce eggs (0-1 eggs), whereas fleas from dogs in the control group continued to produce eggs (1-141 eggs).
In a 90-day US field study conducted in households with varying flea intensities, NexGard’s efficacy against fleas was 98.0%, 99.7%, and 99.9% from baseline at days 30, 60, and 90.
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Overall, data from three studies (two laboratory and one field) show that NexGard kills fleas before they lay eggs, thus preventing subsequent flea infestations after the current flea treatment is started.
In a safety study, NexGard was administered orally to 8- to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) after three treatments every 28 days. every 14 days, for a total of six treatments. Control group dogs were sham dosed. There were no clinically relevant treatment-related effects on physical examination, body weight, food intake, clinical pathology (hematology, clinical chemistry, or coagulation tests), gross pathology, histopathology, or organ weight. Vomiting occurred during the study, including one dog in the 5x group that vomited four hours after treatment, which was similar in the treated and control groups.
In a well-controlled field study, NexGard was used concurrently with other drugs such as vaccines, anthelmintics, antibiotics (including topical), steroids, NSAIDs, anesthetics, and antihistamines. No adverse reactions were observed when NexGard was used simultaneously with other drugs.
If a dose is missed, administer the usual dose of NexGard Chewable and continue with the monthly dosing schedule.
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NexGard chewables require a prescription. Give the appropriate dose based on your dog’s weight. (See how to use). If any dose is suspected to be missed or vomiting occurs within two hours, repeat with another full dose. NexGard chewables can be used with or without food. NexGard chews should be used year-round. Treat all pets in your household to reduce the risk of flea infestation.
Commonly reported adverse reactions include vomiting, dry/scaly skin, diarrhea, lethargy, and loss of appetite. The occurrence of vomiting was generally self-limited and short-lived and decreased with subsequent doses. There are no known contraindications to the use of NexGard Chewables.
The active ingredient in NexGard chewables is Afoxolaner. NexGard Chewables kill adult fleas and are indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of the American dog tick.
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